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Control of traveling waves in the Mammalian cortex.

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January, 2005

Source URL:  https://www.ncbi.nlm.nih.gov/pubmed/15698234?

Control of traveling waves in the Mammalian cortex.

Richardson KA1, Schiff SJ, Gluckman BJ.
Author information
Krasnow Institute for Advanced Study
George Mason University
Fairfax, Virginia 22030, USA.

Abstract

We experimentally confirmed predictions that modulation of the neuronal threshold with electrical fields can speed up, slow down, and even block traveling waves in neocortical slices. The predictions are based on a Wilson-Cowan-type integro-differential equation model of propagating neocortical activity. Wave propagation could be modified quickly and reversibly within targeted regions of the network. To the best of our knowledge, this is the first example of direct modulation of the threshold to control wave propagation in a neural system.

We therefore predicted that we could speed up, slow down, and block propagating neural activity in neocortical slices with the application of electric fields. Furthermore, we predicted that we could affect wave propagation either globally, over the whole slice, or locally, in a specific region of the slice, by changing the geometry of the applied field.

We experimentally confirmed theoretical predictions that threshold modulation can increase or decrease the propagation speed of, and even block, cortical traveling waves. To the best of our knowledge, this is the first example of direct modulation of threshold to control wave propagation in a neural system. Such modulation could be applied rapidly in a locally precise manner. Since neural systems permit direct access to threshold, these findings open avenues to novel neural prosthetic applications including control and containment of seizure propagation.

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